Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 4/20 | 0.36 |
| ▸ | RORA | P35398 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | RORB | Q92753 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6517718 | 0.88 | CHEK1 (0.77) | CHEK1KCNH2PLK1RORARORC | |
| Hydrochloric Acid SCHEMBL6522382 | 0.87 | CHEK1 (0.76) | CHEK1KCNH2PLK1RORARORC | |
| SCHEMBL6522826 | 0.86 | CHEK1 (0.74) | CHEK1KCNH2PLK1RORARORC | |
| SCHEMBL6508600 | 0.86 | CHEK1 (0.74) | CHEK1KCNH2PLK1RORARORC | |
| SCHEMBL6513905 | 0.85 | CHEK1 (0.73) | CHEK1KCNH2PLK1RORARORC | |
| SCHEMBL6513422 | 0.84 | CHEK1 (0.71) | CHEK1KCNH2PLK1RORARORC | |
| SCHEMBL6510275 | 0.83 | CHEK1 (0.70) | CHEK1KCNH2PLK1MAPK8 | |
| SCHEMBL6513681 | 0.83 | CHEK1 (0.70) | CHEK1KCNH2PLK1MAPK8 | |
| SCHEMBL6517703 | 0.83 | CHEK1 (1.00) | CHEK1KCNH2PLK1 | |
| SCHEMBL6510286 | 0.83 | CHEK1 (0.76) | CHEK1KCNH2PLK1RORARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-03 | — | — | US | disclosed |
| WO-2005028474-A2 | PYRAZOLOQUINOLINE DERIVATIVES AS CHK-1 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | CHKA, CHKB, CHEK1 | CHEK1 3/4885KCNH2 3052/4885PLK1 151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.