Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 11/20 | 0.36 |
| ▸ | CNR2 | P34972 | 8/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506902 | 0.85 | CNR1 (0.44) | ADORA2AADORA1ADORA2BKMT2ANPC1 | |
| SCHEMBL6507869 | 0.81 | CNR1 (0.49) | ADORA2AADORA1ADORA2BCNR1 | |
| SCHEMBL4842601 | 0.79 | SRC (0.41) | KMT2ANPC1MEN1RAB9ANPSR1 | |
| SCHEMBL4836399 | 0.79 | CNR1 (0.38) | ADORA2AADORA1ADORA2BKMT2ANPC1 | |
| SCHEMBL5380218 | 0.77 | NPC1 (0.47) | ADORA2AADORA1ADORA2BKMT2ANPC1 | |
| SCHEMBL5377986 | 0.76 | KMT2A (0.48) | KMT2ANPC1MEN1RAB9ANPSR1 | |
| SCHEMBL5380215 | 0.76 | NPC1 (0.62) | KMT2ANPC1MEN1RAB9ANPSR1 | |
| SCHEMBL4832926 | 0.75 | CNR1 (0.45) | KMT2ANPC1MEN1RAB9ANPSR1 | |
| SCHEMBL5375812 | 0.75 | NPC1 (0.45) | ADORA2AADORA1ADORA2BKMT2ANPC1 | |
| SCHEMBL4833400 | 0.75 | SRC (0.39) | KMT2ANPC1MEN1RAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005049615-A1 | PYRAZOLO`1,5-A!`1,3,5! TRIAZIN -4-ONE DERIVATIVES AS CB1 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-06-02 | — | — | WO | claimed |
| WO-2005049615-A1 | PYRAZOLO`1,5-A!`1,3,5! TRIAZIN -4-ONE DERIVATIVES AS CB1 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2005-06-02 | — | — | WO | disclosed |