Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6513492 | 1.00 | GRM5 (0.43) | GRM5MAPTMEN1KMT2AHTT | |
| SCHEMBL6511712 | 0.89 | GRM5 (0.42) | GRM5MAPTMEN1KMT2AHTT | |
| SCHEMBL6515185 | 0.89 | GRM5 (0.42) | GRM5MAPTMEN1KMT2AHTT | |
| SCHEMBL6511706 | 0.89 | GRM5 (0.42) | GRM5MAPTMEN1KMT2AHTT | |
| SCHEMBL6512272 | 0.85 | GRM5 (0.46) | GRM5MAPTMEN1KMT2AHTT | |
| SCHEMBL6512270 | 0.85 | GRM5 (0.46) | GRM5MAPTMEN1KMT2AHTT | |
| SCHEMBL6511677 | 0.82 | GRM5 (0.46) | GRM5MAPTMEN1KMT2AHTT | |
| SCHEMBL6511672 | 0.82 | GRM5 (0.46) | GRM5MAPTMEN1KMT2AHTT | |
| SCHEMBL6512288 | 0.81 | GRM5 (0.44) | GRM5MAPTMEN1KMT2AHTT | |
| SCHEMBL6512297 | 0.81 | GRM5 (0.44) | GRM5MAPTMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050148643-A1 | Carbamate compositions and methods fo rmodulating the activity of the CHK1 enzyme | AGOURON PHARMACEUTICALS, INC. | 2005-07-07 | — | — | US | claimed |
| US-20050148643-A1 | Carbamate compositions and methods fo rmodulating the activity of the CHK1 enzyme | AGOURON PHARMACEUTICALS, INC. | 2005-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148643-A1 | Carbamate compositions and methods fo rmodulating the activity of the CHK1 enzyme | CHEK1, CHEK2, RAD1 | GRM5 4202/4885MAPT 3549/4885MEN1 1178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.