Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 3/20 | 0.40 |
| ▸ | NOS1 | P29475 | 3/20 | 0.40 |
| ▸ | NOS2 | P35228 | 2/20 | 0.40 |
| ▸ | FNTA | P49354 | 2/20 | 0.40 |
| ▸ | FNTB | P49356 | 2/20 | 0.40 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.40 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | BHMT | Q93088 | 7/20 | 0.38 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL27896158 | 1.00 | OTC (0.42) | OTCNOS3NOS1NOS2FNTA | |
| Arginine SCHEMBL9234547 | 0.95 | OTC (0.46) | OTCNOS3NOS1NOS2FNTA | |
| Arginine SCHEMBL1766047 | 0.95 | OTC (0.46) | OTCNOS3NOS1NOS2FNTA | |
| Arginine SCHEMBL1766048 | 0.95 | OTC (0.46) | OTCNOS3NOS1NOS2FNTA | |
| Arginine SCHEMBL13684847 | 0.95 | OTC (0.46) | OTCNOS3NOS1NOS2FNTA | |
| Arginine SCHEMBL15194117 | 0.95 | OTC (0.46) | OTCNOS3NOS1NOS2FNTA | |
| Arginine SCHEMBL27696870 | 0.92 | GSR (0.45) | OTCNOS3NOS1NOS2FNTA | |
| Arginine SCHEMBL27363190 | 0.91 | GSR (0.51) | OTCNOS3NOS1NOS2FNTA | |
| Arginine SCHEMBL27597219 | 0.91 | OTC (0.43) | OTCNOS3NOS1NOS2FNTA | |
| Arginine SCHEMBL27729914 | 0.90 | OTC (0.42) | OTCNOS3NOS1NOS2FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050058651-A1 | Compositions and methods to prevent metastasis from primary malignancies | TRUSTEES OF BOSTON UNIVERSITY, THE | 2005-03-17 | — | — | US | disclosed |
| WO-2002076389-A2 | COMPOSITIONS AND METHODS TO PREVENT METASTASIS FROM PRIMARY MALIGNANCIES | THE TRUSTEES OF BOSTON UNIVERSITY (US) | 2002-10-03 | — | — | WO | disclosed |