Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | F2R | P25116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650053 | 0.92 | C5AR1 (0.38) | C5AR1PTGDR2NR1H4MEN1KMT2A | |
| SCHEMBL649048 | 0.91 | C5AR1 (0.49) | C5AR1CRHR1PTGDR2NR1H4ALDH1A1 | |
| SCHEMBL652511 | 0.90 | C5AR1 (0.39) | C5AR1PTGDR2ALDH1A1MAPK1OPRM1 | |
| SCHEMBL648590 | 0.90 | C5AR1 (0.40) | C5AR1PTGDR2ALDH1A1MAPK1OPRM1 | |
| SCHEMBL648144 | 0.89 | C5AR1 (0.49) | C5AR1PTGDR2ALDH1A1MAPK1OPRM1 | |
| SCHEMBL649515 | 0.88 | C5AR1 (0.43) | C5AR1MEN1KMT2ASMN1; SMN2F2R | |
| SCHEMBL650376 | 0.87 | C5AR1 (0.38) | C5AR1PTGDR2ALDH1A1MAPK1OPRM1 | |
| SCHEMBL649823 | 0.87 | C5AR1 (0.55) | C5AR1ALDH1A1LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL651244 | 0.86 | C5AR1 (0.44) | C5AR1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL1913080 | 0.83 | C5AR1 (0.43) | C5AR1ALDH1A1MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |