Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.49 |
| ▸ | PLK1 | P53350 | 11/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6514638 | 0.81 | CHEK1 (0.59) | CHEK1ALDH1A1KCNH2 | |
| SCHEMBL6509536 | 0.81 | CHEK1 (0.58) | CHEK1PLK1HTTALDH1A1MEN1 | |
| SCHEMBL6512770 | 0.80 | AURKA (0.50) | CHEK1MEN1MAPTKMT2A | |
| SCHEMBL6522416 | 0.80 | MAPT (0.49) | CHEK1MEN1MAPTKMT2A | |
| SCHEMBL6521425 | 0.80 | CHEK1 (0.60) | CHEK1ALDH1A1KCNH2 | |
| SCHEMBL6510884 | 0.79 | CHEK1 (0.56) | CHEK1ALDH1A1KCNH2 | |
| SCHEMBL6517619 | 0.78 | CHEK1 (0.77) | CHEK1PLK1ALDH1A1KCNH2 | |
| SCHEMBL6508848 | 0.78 | AURKA (0.54) | CHEK1PLK1ALDH1A1KMT2AKCNH2 | |
| SCHEMBL6517711 | 0.77 | CHEK1 (0.55) | CHEK1PLK1ALDH1A1MAPTKCNH2 | |
| SCHEMBL6517612 | 0.77 | CHEK1 (0.58) | CHEK1HTTALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | CHKA, CHKB, CHEK1 | CHEK1 3/4885PLK1 151/4885HTT 4407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.