Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.36 |
| ▸ | WEE1 | P30291 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6522817 | 0.84 | CHEK1 (0.39) | ALDH1A1LMNANPSR1KMT2AMAPT | |
| SCHEMBL6514165 | 0.82 | CHEK1 (0.39) | ALDH1A1LMNANPSR1KMT2AMAPT | |
| SCHEMBL6511866 | 0.81 | CHEK1 (0.38) | ALDH1A1LMNAKMT2AMAPTCNR2 | |
| SCHEMBL6511094 | 0.80 | CHEK1 (0.41) | ALDH1A1LMNANPSR1KMT2AMAPT | |
| SCHEMBL6522000 | 0.80 | CHEK1 (0.41) | ALDH1A1LMNAKMT2AMAPTCNR2 | |
| SCHEMBL6516690 | 0.79 | CHEK1 (0.42) | ALDH1A1LMNAKMT2AMAPTCNR2 | |
| SCHEMBL6515376 | 0.78 | MAPT (0.41) | LMNAKMT2AMAPTMEN1CNR2 | |
| SCHEMBL6511097 | 0.77 | IDH1 (0.33) | KMT2ACNR2CHEK1 | |
| SCHEMBL6511027 | 0.76 | ATR (0.42) | CNR2CHEK1 | |
| SCHEMBL6510585 | 0.76 | ATR (0.37) | ALDH1A1NPSR1KMT2ACNR2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | CHKA, CHKB, CHEK1 | ALDH1A1 4635/4885LMNA 2457/4885NPSR1 4840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.