Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 5/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3555150 | 0.76 | GCGR (0.58) | GCGRMAPK14PSDGSK3BMAPK13 | |
| SCHEMBL5215641 | 0.68 | MAPK14 (0.71) | GCGRMAPK14GSK3BMAPK13MAPK12 | |
| SCHEMBL17457312 | 0.68 | CSF1R (0.70) | CSF1RMAPK14CDK5CDK5R1GSK3A | |
| SCHEMBL5255543 | 0.67 | MAPK11 (0.52) | GCGRIKBKBMAP3K14MAPK14MAPK13 | |
| SCHEMBL5214789 | 0.67 | GCGR (0.46) | GCGRCSF1RMAPK14PSDMAPK13 | |
| SCHEMBL27224358 | 0.66 | GSK3B (0.50) | GCGRCSF1RMAPK14PSDGSK3B | |
| SCHEMBL14680953 | 0.66 | MAPT (0.58) | — | |
| SCHEMBL6936901 | 0.66 | GCGR (0.67) | GCGRMAPK14 | |
| SCHEMBL3554322 | 0.66 | CNR1 (0.57) | GCGRMAPK14PSDMAPK13MAPK12 | |
| SCHEMBL196861 | 0.66 | GCGR (0.67) | GCGRMAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506186-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003099808-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2003-12-04 | — | — | WO | disclosed |