Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 19/20 | 0.65 |
| ▸ | KDR | P35968 | 19/20 | 0.65 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6888385 | 0.88 | CDK1 (0.53) | CDK1KDR | |
| SCHEMBL6509042 | 0.87 | CDK1 (0.70) | CDK1KDRABL1PDGFRBSRC | |
| SCHEMBL6511549 | 0.87 | CDK1 (0.49) | CDK1KDR | |
| SCHEMBL6519455 | 0.87 | CDK1 (0.68) | CDK1KDR | |
| SCHEMBL6532726 | 0.85 | CDK1 (0.46) | CDK1KDR | |
| SCHEMBL6517890 | 0.82 | CDK1 (0.54) | CDK1KDRABL1PDGFRBSRC | |
| SCHEMBL6508424 | 0.79 | CDK1 (1.00) | CDK1KDR | |
| SCHEMBL6532732 | 0.79 | CDK1 (0.40) | CDK1KDR | |
| SCHEMBL6888387 | 0.77 | CDK1 (0.47) | CDK1KDR | |
| SCHEMBL6510344 | 0.76 | EGFR (0.41) | CDK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050171134-A1 | 4,5-Disubstituted-2-aminopyrimidines | CELLTECH R&D LIMITED | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171134-A1 | 4,5-Disubstituted-2-aminopyrimidines | FLT1, FLT4, FGFR1 | CDK1 435/4885KDR 8/4885ABL1 301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.