Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.85 |
| ▸ | AKT2 | P31751 | 20/20 | 0.85 |
| ▸ | AKT3 | Q9Y243 | 20/20 | 0.85 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.77 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6520151 | 1.00 | AKT1 (0.85) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL12787766 | 0.94 | AKT1 (0.86) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL17424848 | 0.94 | AKT1 (0.86) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL191720 | 0.94 | AKT1 (0.86) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL17424831 | 0.92 | AKT1 (1.00) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL190846 | 0.92 | AKT1 (1.00) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| Hydrochloric Acid SCHEMBL191069 | 0.91 | AKT1 (0.98) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL17424857 | 0.90 | AKT1 (0.84) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL191781 | 0.90 | AKT1 (0.84) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL192043 | 0.89 | AKT1 (0.86) | AKT1AKT2AKT3PIK3CAPRKG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160152574-A9 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2016-06-02 | — | — | US | disclosed |
| US-20140357644-A1 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2014-12-04 | — | — | US | disclosed |
| US-8835434-B2 | Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2014-09-16 | — | — | US | disclosed |
| EP-2247578-B1 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2013-05-22 | — | — | EP | disclosed |
| US-20110065716-A1 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357644-A1 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | PIK3CA, AKT1, AKT2 | AKT1 2/4885AKT2 3/4885AKT3 5/4885 |
| US-20110065716-A1 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | PIK3CA, AKT1, AKT2 | AKT1 2/4885AKT2 3/4885AKT3 6/4885 |
| US-20160152574-A9 | HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | PIK3CA, AKT1, AKT2 | AKT1 2/4885AKT2 3/4885AKT3 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.