Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 8/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6521943 | 1.00 | CHEK1 (0.52) | CHEK1MAPK8MAPK9MAPK10PLK1 | |
| SCHEMBL6514619 | 1.00 | CHEK1 (0.52) | CHEK1MAPK8MAPK9MAPK10PLK1 | |
| SCHEMBL6514622 | 0.85 | CHEK1 (0.54) | CHEK1MAPK8MAPK9MAPK10PLK1 | |
| SCHEMBL6513681 | 0.85 | CHEK1 (0.70) | CHEK1MAPK8MAPK9MAPK10PLK1 | |
| SCHEMBL6509676 | 0.83 | CHEK1 (0.73) | CHEK1PLK1KCNH2CYP1A2CYP3A4 | |
| SCHEMBL6518282 | 0.83 | CHEK1 (0.73) | CHEK1PLK1KCNH2CYP1A2CYP3A4 | |
| SCHEMBL6509674 | 0.83 | CHEK1 (0.73) | CHEK1PLK1KCNH2CYP1A2CYP3A4 | |
| SCHEMBL6515401 | 0.80 | CHEK1 (0.69) | CHEK1MAPK8MAPK9MAPK10PLK1 | |
| SCHEMBL6519912 | 0.80 | CHEK1 (0.68) | CHEK1MAPK8MAPK9MAPK10PLK1 | |
| SCHEMBL6510497 | 0.80 | CHEK1 (0.55) | CHEK1MAPK8MAPK9MAPK10PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | CHKA, CHKB, CHEK1 | CHEK1 3/4885MAPK8 391/4885MAPK9 284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.