Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21883515 | 0.87 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2POLBKMT2A | |
| SCHEMBL32665823 | 0.87 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2POLBKMT2A | |
| SCHEMBL6003843 | 0.76 | ELANE (0.52) | RAB9ASMN1; SMN2POLBKMT2AHTT | |
| SCHEMBL21883132 | 0.74 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2POLBKMT2A | |
| SCHEMBL32665830 | 0.74 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2POLBKMT2A | |
| SCHEMBL6178671 | 0.73 | KMT2A (0.62) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL31432059 | 0.73 | GRM4 (0.66) | NPC1RAB9ASMN1; SMN2POLBKMT2A | |
| SCHEMBL31587999 | 0.71 | POLB (0.58) | POLBKMT2AMEN1ALDH1A1RECQL | |
| SCHEMBL1884170 | 0.70 | MEN1 (0.74) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL24221999 | 0.70 | POLB (0.55) | NPC1RAB9ASMN1; SMN2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603897-A1 | PYRAZOLE COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004080999-A1 | PYRAZOLE COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2004-09-23 | — | — | WO | disclosed |