Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 6/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 17/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4313201 | 0.85 | HDAC2 (0.50) | HDAC2HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL651965 | 0.84 | HDAC1 (0.64) | HDAC2HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL2212580 | 0.82 | HDAC1 (0.54) | HDAC2HDAC1HDAC3 | |
| SCHEMBL651416 | 0.82 | HDAC1 (0.58) | HDAC2HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL653692 | 0.82 | HDAC1 (0.50) | HDAC2HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL1930977 | 0.81 | HDAC1 (0.53) | HDAC2HDAC1HDAC3 | |
| SCHEMBL1931687 | 0.81 | HDAC1 (0.53) | HDAC2HDAC1HDAC3 | |
| SCHEMBL1931248 | 0.81 | HDAC1 (0.55) | HDAC2HDAC1HDAC3 | |
| SCHEMBL1931101 | 0.80 | HDAC1 (0.52) | HDAC2HDAC1HDAC3 | |
| SCHEMBL650414 | 0.79 | HDAC1 (0.52) | HDAC2HDAC1HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119685-B2 | Disubstituted aniline compounds | MERCK SHARP & DOHME CORP. (US) | 2012-02-21 | — | — | US | disclosed |