Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ATP4A | P20648 | 2/20 | 0.31 |
| ▸ | ATP4B | P51164 | 2/20 | 0.31 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | MMP13 | P45452 | 2/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1913005 | 0.91 | C5AR1 (0.42) | C5AR1TSHRALDH1A1HTTLMNA | |
| SCHEMBL651033 | 0.91 | C5AR1 (0.44) | C5AR1TSHRALDH1A1HTTLMNA | |
| SCHEMBL651956 | 0.90 | C5AR1 (0.43) | C5AR1TSHRALDH1A1HTTLMNA | |
| SCHEMBL650473 | 0.89 | C5AR1 (0.41) | C5AR1TSHRALDH1A1HTTLMNA | |
| SCHEMBL649882 | 0.89 | C5AR1 (0.41) | C5AR1TSHRALDH1A1HTTLMNA | |
| SCHEMBL649675 | 0.88 | C5AR1 (0.42) | C5AR1TSHRALDH1A1HTTLMNA | |
| SCHEMBL648790 | 0.88 | C5AR1 (0.43) | C5AR1TSHRALDH1A1HTTLMNA | |
| SCHEMBL650263 | 0.88 | C5AR1 (0.41) | C5AR1TSHRALDH1A1HTTBCHE | |
| SCHEMBL650574 | 0.88 | C5AR1 (0.41) | C5AR1TSHRALDH1A1HTTBCHE | |
| SCHEMBL647750 | 0.88 | C5AR1 (0.39) | C5AR1TSHRALDH1A1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |