Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | RORA | P35398 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | RORB | Q92753 | 2/20 | 0.38 |
| ▸ | TERT | O14746 | 2/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6522894 | 0.89 | CHEK1 (0.65) | CHEK1KCNH2TERTTMEM97 | |
| SCHEMBL6516378 | 0.83 | CHEK1 (0.49) | CHEK1KCNH2 | |
| SCHEMBL6515415 | 0.82 | CHEK1 (0.58) | CHEK1KCNH2TERTSIGMAR1 | |
| SCHEMBL6046793 | 0.81 | CHEK1 (0.50) | CHEK1KCNH2TERT | |
| SCHEMBL6518745 | 0.80 | CHEK1 (0.65) | CHEK1KCNH2TMEM97 | |
| SCHEMBL6517718 | 0.80 | CHEK1 (0.77) | CHEK1KCNH2RORARORCRORB | |
| Hydrochloric Acid SCHEMBL6522382 | 0.79 | CHEK1 (0.76) | CHEK1KCNH2RORARORCRORB | |
| SCHEMBL6514957 | 0.78 | CHEK1 (0.56) | CHEK1KCNH2RORARORCRORB | |
| SCHEMBL6523697 | 0.77 | CHEK1 (0.72) | CHEK1KCNH2RORARORCRORB | |
| SCHEMBL6507940 | 0.77 | CHEK1 (0.75) | CHEK1KCNH2RORARORCRORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-03 | — | — | US | disclosed |
| WO-2005028474-A2 | PYRAZOLOQUINOLINE DERIVATIVES AS CHK-1 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | CHKA, CHKB, CHEK1 | CHEK1 3/4885KCNH2 3052/4885RORA 4609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.