Sugi Predict

Sugi Predict / Compounds / SCHEMBL652463

SCHEMBL652463

SCHEMBL652463

CCCCn1c(-c2ccccc2)nc(-c2ccccc2)c1CN(Cc1ccccc1)Cc1cc(C)c(OS(C)(=O)=O)c(C)c1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ C5AR1 P21730 1/20 0.41
▸ TSHR P16473 4/20 0.38
▸ KDM4E B2RXH2 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ CRHR1 P34998 2/20 0.34
▸ LMNA P02545 2/20 0.33
▸ HTT P42858 2/20 0.33
▸ PDE4B Q07343 2/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ PPARG P37231 1/20 0.32
▸ PPARA Q07869 1/20 0.32
▸ CNR2 P34972 2/20 0.32
▸ CNR1 P21554 1/20 0.32
▸ NPSR1 Q6W5P4 1/20 0.32
▸ NR1H3 Q13133 1/20 0.32
▸ ADORA2B P29275 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL649779 0.94 C5AR1 (0.40) C5AR1TSHRKDM4EALDH1A1HPGD
SCHEMBL647724 0.88 C5AR1 (0.44) C5AR1TSHRKDM4EALDH1A1HPGD
SCHEMBL648990 0.86 C5AR1 (0.43) C5AR1TSHRKDM4EALDH1A1HPGD
SCHEMBL650339 0.85 C5AR1 (0.41) C5AR1TSHRKDM4EALDH1A1HPGD
SCHEMBL651094 0.84 TSHR (0.50) C5AR1TSHRKDM4EALDH1A1HPGD
SCHEMBL4766543 0.84 C5AR1 (0.45) C5AR1TSHRKDM4EALDH1A1HPGD
SCHEMBL652063 0.84 C5AR1 (0.40) C5AR1TSHRKDM4EALDH1A1HSD17B10
SCHEMBL650206 0.83 C5AR1 (0.43) C5AR1TSHRKDM4EALDH1A1HPGD
SCHEMBL650679 0.81 C5AR1 (0.43) C5AR1TSHRKDM4EALDH1A1HPGD
SCHEMBL5135922 0.81 C5AR1 (0.49) C5AR1TSHRKDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8795824-B2 Light diffusing resin composition and light diffusing plate using the same IDEMITSU KOSAN CO., LTD. (JP) 2014-08-05 — — US disclosed
US-8119228-B2 Polycarbonate resin composition, optical molded body using the same, and illumination unit IDEMITSU KOSAN CO., LTD. (JP) 2012-02-21 — — US disclosed
US-8119665-B2 Aryl imidazoles and related compounds as C5a receptor modulators NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) 2012-02-21 — — US disclosed
US-8119665-B2 Aryl imidazoles and related compounds as C5a receptor modulators NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) 2012-02-21 — — US disclosed
US-8119665-B2 Aryl imidazoles and related compounds as C5a receptor modulators NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) 2012-02-21 — — US disclosed
US-20090186208-A1 LIGHT DIFFUSING RESIN COMPOSITION AND LIGHT DIFFUSING PLATE USING THE SAME IDEMITSU KOSAN CO., LTD. (JP) 2009-07-23 — — US disclosed
US-20090185363-A1 POLYCARBONATE RESIN COMPOSITION, OPTICAL MOLDED BODY USING THE SAME, AND ILLUMINATION UNIT IDEMITSU KOSAN CO., LTD. (JP) 2009-07-23 — — US disclosed
EP-1490044-A4 COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS NEUROGEN CORP (US) 2008-04-16 — — EP disclosed
US-7186734-B2 Aryl imidazoles and related compounds as C5a receptor modulators NEUROGEN CORPORATION (US) 2007-03-06 — — US disclosed
US-7186734-B2 Aryl imidazoles and related compounds as C5a receptor modulators NEUROGEN CORPORATION (US) 2007-03-06 — — US disclosed
US-7186734-B2 Aryl imidazoles and related compounds as C5a receptor modulators NEUROGEN CORPORATION (US) 2007-03-06 — — US disclosed
EP-1490044-A1 COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS NEUROGEN CORPORATION (US) 2004-12-29 — — EP disclosed
WO-2003084524-A1 COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS NEUROGEN CORPORATION (US) 2003-10-16 — — WO disclosed