Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.58 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12797765 | 0.94 | SYK (0.53) | SYKNOS3NOS1NOS2PDE5A | |
| SCHEMBL6521653 | 0.90 | SYK (0.50) | SYKNOS3NOS1NOS2PDE5A | |
| SCHEMBL6524282 | 0.90 | SYK (0.50) | SYKNOS3NOS1NOS2PDE5A | |
| SCHEMBL6526540 | 0.90 | SYK (0.50) | SYKNOS3NOS1NOS2PDE5A | |
| SCHEMBL6522244 | 0.90 | SYK (0.50) | SYKNOS3NOS1NOS2PDE5A | |
| SCHEMBL6526554 | 0.89 | SYK (0.49) | SYKNOS3NOS1NOS2PDE5A | |
| SCHEMBL1158197 | 0.89 | SYK (0.67) | SYKNOS3NOS1NOS2 | |
| SCHEMBL6523221 | 0.88 | SYK (0.56) | SYK | |
| SCHEMBL12795738 | 0.87 | SYK (0.75) | SYKNOS3NOS1NOS2MAP3K12 | |
| SCHEMBL12795799 | 0.87 | SYK (0.75) | SYKNOS3NOS1NOS2MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110053897-A1 | COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2011-03-03 | — | — | US | claimed |
| US-20110053897-A1 | COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053897-A1 | COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS | SYK, BTK, LYN | SYK 1/4885NOS3 703/4885NOS1 737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.