Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.80 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.80 |
| ▸ | LCK | P06239 | 11/20 | 0.53 |
| ▸ | JAK2 | O60674 | 8/20 | 0.51 |
| ▸ | JAK3 | P52333 | 8/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3144850 | 1.00 | AURKA (0.80) | AURKAAURKBLCKJAK2JAK3 | |
| SCHEMBL3145171 | 0.91 | AURKA (0.83) | AURKAAURKBLCKJAK2JAK3 | |
| SCHEMBL3137876 | 0.91 | AURKA (0.83) | AURKAAURKBLCKJAK2JAK3 | |
| SCHEMBL5590529 | 0.91 | AURKA (0.83) | AURKAAURKBLCKJAK2JAK3 | |
| SCHEMBL13666776 | 0.89 | AURKA (1.00) | AURKAAURKBLCKJAK2JAK3 | |
| SCHEMBL6527997 | 0.89 | AURKA (0.80) | AURKAAURKBLCKJAK2JAK3 | |
| SCHEMBL3143501 | 0.89 | AURKA (0.80) | AURKAAURKBLCKJAK2JAK3 | |
| SCHEMBL13313163 | 0.89 | AURKA (1.00) | AURKAAURKBLCKJAK2JAK3 | |
| SCHEMBL13666779 | 0.89 | AURKA (0.80) | AURKAAURKBLCKJAK2JAK3 | |
| SCHEMBL3147902 | 0.89 | AURKA (1.00) | AURKAAURKBLCKJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511742-A1 | KINASE INHIBITORS | Cytopia PTY Ltd (AU) | 2005-03-09 | — | — | EP | claimed |
| WO-2003099811-A1 | KINASE INHIBITORS | CYTOPIA PTY LTD (AU) | 2003-12-04 | — | — | WO | claimed |
| EP-1511742-A1 | KINASE INHIBITORS | Cytopia PTY Ltd (AU) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003099811-A1 | KINASE INHIBITORS | CYTOPIA PTY LTD (AU) | 2003-12-04 | — | — | WO | disclosed |