Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 20/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.65 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | LYN | P07948 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | HCK | P08631 | 1/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.57 |
| ▸ | KIT | P10721 | 1/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.57 |
| ▸ | RAB6A | P20340 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
| ▸ | MST1R | Q04912 | 1/20 | 0.57 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.57 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5489361 | 0.98 | AURKA (0.66) | AURKAAURKBRIPK2EGFRLCK | |
| SCHEMBL5491635 | 0.88 | AURKA (0.69) | AURKAAURKBRIPK2EGFRLCK | |
| SCHEMBL3490562 | 0.86 | AURKA (0.84) | AURKAAURKBRIPK2EGFRLCK | |
| SCHEMBL3488623 | 0.86 | AURKA (0.71) | AURKAAURKBRIPK2EGFRLCK | |
| SCHEMBL2050460 | 0.85 | FLT4 (0.67) | AURKAAURKBEGFRPDGFRBKDR | |
| SCHEMBL3489055 | 0.84 | AURKA (0.72) | AURKAAURKBRIPK2EGFRLCK | |
| SCHEMBL3489845 | 0.82 | AURKA (0.85) | AURKAAURKB | |
| SCHEMBL3489274 | 0.82 | AURKA (0.84) | AURKAAURKB | |
| SCHEMBL3489398 | 0.81 | AURKA (0.74) | AURKAAURKBRIPK2EGFRLCK | |
| SCHEMBL6525973 | 0.81 | AURKA (0.84) | AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578755-A1 | PHOSPHONOOXY QUINAZOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | AstraZeneca AB (SE) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004058781-A1 | PHOSPHONOOXY QUINAZOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | disclosed |