SCHEMBL6527653

SCHEMBL6527653

Cc1cc(OCc2ccc(F)cc2F)c(Cl)c(=O)n1-c1ccn([S+](C)[O-])c1

nearest known ligand 0.63

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 19/20 0.63
MAPKAPK2 P49137 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4382651 0.84 MAPK14 (0.62) MAPK14
SCHEMBL4476275 0.83 MAPK14 (0.64) MAPK14MAPKAPK2
SCHEMBL4472519 0.83 MAPK14 (0.63) MAPK14
SCHEMBL4489341 0.81 MAPK14 (0.61) MAPK14
SCHEMBL4478353 0.80 MAPK14 (0.57) MAPK14MAPKAPK2
SCHEMBL4474292 0.80 MAPK14 (0.59) MAPK14MAPKAPK2
SCHEMBL4478069 0.80 MAPK14 (0.59) MAPK14
SCHEMBL4374118 0.79 MAPK14 (0.87) MAPK14MAPKAPK2
SCHEMBL4480020 0.79 MAPK14 (0.58) MAPK14
SCHEMBL4382467 0.77 MAPK14 (1.00) MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005018557-A2 SUBSTITUTED PYRIDINONES PHARMACIA CORPORATION (US) 2005-03-03 WO disclosed