Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.49 |
| ▸ | MAP2K2 | P36507 | 13/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5622768 | 1.00 | MAP2K1 (0.49) | MAP2K1MAP2K2IRAK4FLT1KDR | |
| SCHEMBL5623884 | 0.88 | MAP2K1 (0.52) | MAP2K1MAP2K2FLT1KDR | |
| SCHEMBL5623212 | 0.87 | MAP2K1 (0.51) | MAP2K1MAP2K2FLT1KDR | |
| SCHEMBL6208441 | 0.80 | MAP2K1 (0.35) | MAP2K1MAP2K2IRAK4 | |
| SCHEMBL6396688 | 0.80 | MAP2K1 (0.35) | MAP2K1MAP2K2IRAK4 | |
| SCHEMBL6528382 | 0.76 | MAP2K1 (0.66) | MAP2K1MAP2K2 | |
| SCHEMBL5623735 | 0.75 | MAP2K1 (0.52) | MAP2K1MAP2K2FLT1KDR | |
| SCHEMBL5623838 | 0.75 | MAP2K1 (0.52) | MAP2K1MAP2K2FLT1KDR | |
| SCHEMBL5623826 | 0.74 | MAP2K1 (0.52) | MAP2K1MAP2K2KDR | |
| SCHEMBL14425460 | 0.74 | MAP2K1 (0.37) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005000818-A1 | 5-SUBSTITUTED-4-`(SUBSTITUTED PHENYL)!AMINO!-2-PYRIDONE DEVIATIVES FOR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-06 | — | — | WO | disclosed |