Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CES1 | P23141 | 6/20 | 0.39 |
| ▸ | CES2 | O00748 | 6/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10599714 | 0.98 | CA1 (0.41) | CA1CES1CES2CYP4F2CYP4A11 | |
| SCHEMBL10495891 | 0.95 | CA1 (0.39) | CA1CES1CES2CYP4F2CYP4A11 | |
| SCHEMBL332305 | 0.95 | CA1 (0.39) | CA1CES1CES2CYP4F2CYP4A11 | |
| SCHEMBL6889313 | 0.95 | CA1 (0.39) | CA1CES1CES2CYP4F2CYP4A11 | |
| SCHEMBL17472936 | 0.95 | CA1 (0.39) | CA1CES1CES2CYP4F2CYP4A11 | |
| Silver SCHEMBL25380476 | 0.95 | CA1 (0.39) | CA1CES1CES2CYP4F2CYP4A11 | |
| Zinc Ion SCHEMBL546648 | 0.95 | CA1 (0.39) | CA1CES1CES2CYP4F2CYP4A11 | |
| SCHEMBL17476400 | 0.95 | CA1 (0.44) | CA1CES1CES2CYP4F2CYP4A11 | |
| SCHEMBL8939650 | 0.95 | CA1 (0.39) | CA1CES1CES2CYP4F2CYP4A11 | |
| SCHEMBL7649654 | 0.95 | CA1 (0.39) | CA1CES1CES2CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2023924-B1 | ARYL-FUSED SPIROCYCLIC COMPOUNDS | MERCK SHARP & DOHME (US) | 2016-08-03 | — | — | EP | claimed |
| US-20090239849-A1 | Aryl-Fused Spirocyclic Compounds | MERCK SHARP & DOHME LLC | 2009-09-24 | — | — | US | claimed |
| JP-5295271-A | — | — | None | — | — | JP | disclosed |
| JP-5295272-A | — | — | None | — | — | JP | disclosed |
| JP-5320517-A | — | — | None | — | — | JP | disclosed |
| CN-110511373-B | Fluorine-containing organosilicon compound, method for producing same, room-temperature-curable fluorine-containing rubber composition, cured product thereof, and article | 信越化学工业株式会社 | 2024-04-02 | — | — | CN | disclosed |
| CN-116348509-A | Coating composition | 佐敦公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-116323852-A | Composition for sealing covered wire, and covered wire | 东亚合成株式会社 | 2023-06-23 | — | — | CN | disclosed |
| CN-109415594-B | Coating composition | 关西涂料株式会社 | 2021-03-09 | — | — | CN | disclosed |
| EP-3327097-B1 | COATING MATERIAL AND LAMINATE | DAIKIN IND LTD (JP) | 2020-09-16 | — | — | EP | disclosed |
| US-10457835-B2 | Coating agent composition | THREEBOND CO., LTD. (JP) | 2019-10-29 | — | — | US | disclosed |
| JP-H05295271-A | SILICONE COMPOSITION CURABLE WITH MOISTURE AND LIGHT | THREE BOND CO LTD | 1993-11-09 | — | — | JP | disclosed |
| JP-H05295272-A | SILICONE COMPOSITION CURABLE WITH MOISTURE AND LIGHT | THREE BOND CO LTD | 1993-11-09 | — | — | JP | disclosed |
| US-5126171-A | METHOD OF FORMING A SEALANT HAVING ORGANOPOLYSILOXANES AS A MAIN INGREDIENT | THREE BOND CO., LTD. (JP) | 1992-06-30 | — | — | US | disclosed |
| EP-0409079-A2 | A method of forming a sealant having organopolysiloxanes as a main ingredient | THREE BOND CO., LTD. (JP) | 1991-01-23 | — | — | EP | disclosed |
| US-4595445-A | Adhesive is thermosetting reactive polyisocyanate-polyamine activated by heat or polar solvents | BAYER AKTIENGESELLSCHAFT (DE) | 1986-06-17 | — | — | US | disclosed |
| US-4563498-A | LOW MODULUS RUBBERS FREE OF PLASTICIZING FLUID | GENERAL ELECTRIC COMPANY (US) | 1986-01-07 | — | — | US | disclosed |
| US-4555420-A | DIFUNCTIONAL NITROGEN-CONTAINING SILANE CURING AGENTS; LOW MODULUS ENCAPPED POLYSILOXANES | GENERAL ELECTRIC COMPANY (US) | 1985-11-26 | — | — | US | disclosed |
| US-RE29760-E | RUBBER FOR COATING, SEALANT OR CAULK | DOW CORNING CORPORATION (US) | 1978-09-12 | — | — | US | disclosed |
| US-3997496-A | Process for the preparation of fluorosilicone polymers and copolymers | GENERAL ELECTRIC COMPANY (US) | 1976-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239849-A1 | Aryl-Fused Spirocyclic Compounds | HDAC1, BRDT, HDAC5 | CA1 949/4885CES1 2610/4885CES2 3350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.