Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.75 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.75 |
| ▸ | FLT1 | P17948 | 6/20 | 0.75 |
| ▸ | PLK4 | O00444 | 1/20 | 0.75 |
| ▸ | AURKA | O14965 | 1/20 | 0.75 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.75 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.75 |
| ▸ | STK10 | O94804 | 1/20 | 0.75 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.75 |
| ▸ | ABL1 | P00519 | 1/20 | 0.75 |
| ▸ | EGFR | P00533 | 1/20 | 0.75 |
| ▸ | INSR | P06213 | 1/20 | 0.75 |
| ▸ | LCK | P06239 | 1/20 | 0.75 |
| ▸ | FYN | P06241 | 1/20 | 0.75 |
| ▸ | YES1 | P07947 | 1/20 | 0.75 |
| ▸ | LYN | P07948 | 1/20 | 0.75 |
| ▸ | RET | P07949 | 1/20 | 0.75 |
| ▸ | MET | P08581 | 1/20 | 0.75 |
| ▸ | ROS1 | P08922 | 1/20 | 0.75 |
| ▸ | BCR | P11274 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6530758 | 0.93 | KDR (0.65) | KDRPDGFRBFLT1PLK4AURKA | |
| Osi-632 SCHEMBL187261 | 0.86 | KDR (1.00) | KDRPDGFRBFLT1PLK4AURKA | |
| Osi-632 SCHEMBL438781 | 0.85 | KDR (0.98) | KDRPDGFRBFLT1PLK4AURKA | |
| Osi-632 SCHEMBL5705524 | 0.85 | KDR (0.98) | KDRPDGFRBFLT1PLK4AURKA | |
| SCHEMBL6487930 | 0.84 | KDR (0.82) | KDRPDGFRBFLT1PLK4AURKA | |
| SCHEMBL6484366 | 0.84 | KDR (0.77) | KDRPDGFRBFLT1PLK4AURKA | |
| SCHEMBL3084090 | 0.84 | KDR (0.87) | KDRPDGFRBFLT1PLK4AURKA | |
| SCHEMBL3085641 | 0.84 | KDR (0.87) | KDRPDGFRBFLT1PLK4AURKA | |
| Osi-632 SCHEMBL5705560 | 0.83 | KDR (0.94) | KDRPDGFRBFLT1PLK4AURKA | |
| Osi-632 SCHEMBL5705534 | 0.83 | KDR (0.94) | KDRPDGFRBFLT1PLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050256177-A1 | Phenyl derivatives for the treatment of abnormal cell growth | PFIZER INC | 2005-11-17 | — | — | US | claimed |
| WO-2005110406-A2 | PHENYL DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH | PFIZER PRODUCTS INC. (US) | 2005-11-24 | — | — | WO | disclosed |
| US-20050256177-A1 | Phenyl derivatives for the treatment of abnormal cell growth | PFIZER INC | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256177-A1 | Phenyl derivatives for the treatment of abnormal cell growth | CCND3, CDC25C, CCNA1 | KDR 2216/4885PDGFRB 1592/4885FLT1 931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.