Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.89 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.89 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL392754 | 0.94 | BAZ2B (1.00) | BAZ2BBAZ2AMAP2K2MAP2K1TSHR | |
| SCHEMBL392466 | 0.85 | BAZ2B (0.61) | BAZ2BBAZ2AMAP2K2MAP2K1TSHR | |
| SCHEMBL12344058 | 0.79 | BAZ2B (0.72) | BAZ2BBAZ2AMAP2K2MAP2K1TSHR | |
| SCHEMBL23675003 | 0.78 | BAZ2B (0.70) | BAZ2BBAZ2AMAP2K2MAP2K1TSHR | |
| SCHEMBL388580 | 0.78 | BAZ2B (0.70) | BAZ2BBAZ2AMAP2K2MAP2K1TSHR | |
| SCHEMBL31133035 | 0.77 | BAZ2B (0.69) | BAZ2BBAZ2AMAP2K2MAP2K1ALDH1A1 | |
| SCHEMBL10930011 | 0.77 | CYP4F2 (0.55) | BAZ2BBAZ2ATSHRCYP4F2CYP4A11 | |
| SCHEMBL17156673 | 0.77 | BAZ2B (0.68) | BAZ2BBAZ2ACYP4F2CYP4A11CA1 | |
| SCHEMBL17156789 | 0.76 | BAZ2B (0.67) | BAZ2BBAZ2ATSHRCYP4F2CYP4A11 | |
| SCHEMBL23147153 | 0.75 | BAZ2B (0.67) | BAZ2BBAZ2AMAP2K2MAP2K1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005000818-A1 | 5-SUBSTITUTED-4-`(SUBSTITUTED PHENYL)!AMINO!-2-PYRIDONE DEVIATIVES FOR USE AS MEK INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-06 | — | — | WO | disclosed |