Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4937603 | 0.85 | ESR2 (0.49) | GPR119ESR2NR1H2USP30NPC1 | |
| SCHEMBL5077828 | 0.82 | NR1H2 (0.62) | GPR119ESR2NR1H2USP30NPC1 | |
| SCHEMBL1365223 | 0.82 | ESR2 (0.63) | GPR119ESR2NR1H2 | |
| SCHEMBL4936403 | 0.81 | ESR2 (0.46) | GPR119ESR2NR1H2USP30MEN1 | |
| SCHEMBL4937581 | 0.81 | ESR2 (0.46) | GPR119ESR2NR1H2USP30MEN1 | |
| SCHEMBL5446560 | 0.80 | ESR2 (0.64) | GPR119ESR2NR1H2NPC1RAB9A | |
| SCHEMBL5446905 | 0.80 | ESR2 (0.64) | GPR119ESR2NR1H2NPC1RAB9A | |
| SCHEMBL5446908 | 0.80 | ESR2 (0.64) | GPR119ESR2NR1H2NPC1RAB9A | |
| SCHEMBL4933094 | 0.79 | ESR2 (0.53) | ESR2NR1H2MEN1KMT2A | |
| SCHEMBL4929711 | 0.79 | ESR2 (0.53) | ESR2NR1H2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042491-A1 | BENZAZEPINE DERIVATIVES AND METHODS OF PROPHYLAXIS OR TREATMENT OF 5HT2C RECEPTOR ASSOCIATED DISEASES | ARENA PHARMACEUTICALS, INC. (US) | 2005-05-12 | — | — | WO | disclosed |