Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | ATM | Q13315 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | BRD4 | O60885 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5253835 | 1.00 | KDM4E (1.00) | KDM4EATMCYP2D6BRD4ALDH1A1 | |
| SCHEMBL6528941 | 1.00 | KDM4E (1.00) | KDM4EATMCYP2D6BRD4ALDH1A1 | |
| SCHEMBL10212688 | 0.91 | KDM4E (0.84) | KDM4EATMCYP2D6BRD4ALDH1A1 | |
| SCHEMBL30415306 | 0.91 | KDM4E (0.83) | KDM4EATMCYP2D6BRD4ALDH1A1 | |
| SCHEMBL3256692 | 0.91 | KDM4E (0.83) | KDM4EATMCYP2D6BRD4ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27732898 | 0.89 | KDM4E (0.81) | KDM4EATMCYP2D6BRD4ALDH1A1 | |
| SCHEMBL24736335 | 0.87 | KDM4E (0.77) | KDM4EATMCYP2D6BRD4ALDH1A1 | |
| SCHEMBL1720727 | 0.82 | KDM4E (0.70) | KDM4EATMCYP2D6BRD4ALDH1A1 | |
| SCHEMBL19210848 | 0.82 | KDM4E (0.70) | KDM4EATMCYP2D6BRD4ALDH1A1 | |
| SCHEMBL8508491 | 0.81 | KDM4E (0.68) | KDM4EATMCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005066157-A1 | 3-(PYROLIDIN-3-L) INDOLES AS 5-HT6 RECEPTOR MODULATORS | SUVEN LIFE SCIENCES (IN) | 2005-07-21 | — | — | WO | claimed |
| WO-2005066157-A1 | 3-(PYROLIDIN-3-L) INDOLES AS 5-HT6 RECEPTOR MODULATORS | SUVEN LIFE SCIENCES (IN) | 2005-07-21 | — | — | WO | disclosed |
| CN-1051313-C | 5-arylindole derivatives | PFIZER (US) | 2000-04-12 | — | — | CN | disclosed |
| CN-1045294-C | Indole derivatives | PFIZER (US) | 1999-09-29 | — | — | CN | disclosed |
| CN-1094727-A | The 5-(hetero) aryl indole derivatives | PFIZER (US) | 1994-11-09 | — | — | CN | disclosed |
| CN-1072679-A | INDOLE DERIVATIVES | PFIZER (US) | 1993-06-02 | — | — | CN | disclosed |