Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 20/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | TEK | Q02763 | 3/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | PRKCB | P05771 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | PRKCA | P17252 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6530368 | 0.89 | EPHB4 (0.70) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL5480134 | 0.84 | EPHB4 (0.79) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL5482749 | 0.81 | EPHB4 (0.84) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL5475299 | 0.79 | EPHB4 (0.76) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL5486794 | 0.79 | EPHB4 (0.76) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL5479028 | 0.79 | EPHB4 (0.86) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL5486243 | 0.78 | EPHB4 (0.83) | EPHB4KDRTEK | |
| SCHEMBL6533366 | 0.77 | EPHB4 (0.62) | EPHB4KDRTEKABL1EGFR | |
| SCHEMBL5480341 | 0.76 | EPHB4 (0.85) | EPHB4KDRTEK | |
| SCHEMBL5488568 | 0.75 | EPHB4 (0.83) | EPHB4KDRTEKABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019220-A9 | SUBSTITUTED IMIDAZO[1,2-A]PYRAZINES AS MODULATORS OF KINASE ACTIVITY | CELLULAR GENOMICS INC (US) | 2005-06-02 | — | — | WO | disclosed |
| WO-2005019220-A2 | SUBSTITUTED IMIDAZO[1,2-A]PYRAZINES AS MODULATORS OF KINASE ACTIVITY | CELLULAR GENOMICS INC. (US) | 2005-03-03 | — | — | WO | disclosed |