Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 17/20 | 0.74 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.72 |
| ▸ | KDR | P35968 | 2/20 | 0.72 |
| ▸ | EGFR | P00533 | 1/20 | 0.72 |
| ▸ | IGF1R | P08069 | 1/20 | 0.72 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.72 |
| ▸ | SRC | P12931 | 1/20 | 0.72 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.72 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.72 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.72 |
| ▸ | CDK2 | P24941 | 1/20 | 0.72 |
| ▸ | CSK | P41240 | 1/20 | 0.72 |
| ▸ | JAK3 | P52333 | 1/20 | 0.72 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.72 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5045597 | 1.00 | AURKA (0.74) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL5041746 | 1.00 | AURKA (0.74) | AURKAAURKBKDREGFRIGF1R | |
| Hydrochloric Acid SCHEMBL5045485 | 0.99 | AURKA (0.73) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL3884885 | 0.95 | AURKA (0.74) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL3888487 | 0.94 | AURKA (0.68) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL3883326 | 0.93 | AURKA (0.74) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL5041537 | 0.93 | AURKA (0.70) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL3892667 | 0.92 | AURKA (0.69) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL3888650 | 0.92 | AURKA (0.69) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL5048641 | 0.92 | AURKA (0.87) | AURKAAURKBKDREGFRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575946-A1 | QUINAZOLINE COMPOUNDS | AstraZeneca AB (SE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004058752-A1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | disclosed |