Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 15/20 | 0.70 |
| ▸ | KDR | P35968 | 5/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.56 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | CSK | P41240 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048663 | 0.93 | AURKA (0.79) | AURKAKDRAURKBEGFRIGF1R | |
| SCHEMBL6471188 | 0.90 | AURKA (0.69) | AURKAKDRAURKBEGFRIGF1R | |
| SCHEMBL3897202 | 0.90 | AURKA (0.66) | AURKAKDRAURKBEGFRIGF1R | |
| SCHEMBL5046894 | 0.89 | AURKA (0.70) | AURKAKDRAURKBEGFRIGF1R | |
| SCHEMBL5045224 | 0.87 | AURKA (0.68) | AURKAKDRAURKBEGFRIGF1R | |
| SCHEMBL5049211 | 0.87 | AURKA (0.63) | AURKAKDRAURKBEGFRIGF1R | |
| SCHEMBL5045030 | 0.86 | AURKA (0.70) | AURKAKDRAURKBEGFRIGF1R | |
| SCHEMBL5046041 | 0.85 | AURKA (0.74) | AURKAKDRAURKBEGFRIGF1R | |
| SCHEMBL3888165 | 0.85 | AURKA (0.64) | AURKAKDRAURKBEGFRIGF1R | |
| SCHEMBL6470416 | 0.85 | AURKA (0.78) | AURKAKDRAURKBEGFRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575946-A1 | QUINAZOLINE COMPOUNDS | AstraZeneca AB (SE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004058752-A1 | QUINAZOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | disclosed |