Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4371746 | 0.94 | RECQL (0.54) | RECQLUSP2SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL31204 | 0.86 | HSD17B10 (0.49) | RECQLUSP2SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL4038363 | 0.80 | RECQL (0.49) | RECQLUSP2SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL2364954 | 0.77 | HSD17B10 (0.51) | USP2SMN1; SMN2HSD17B10HPGDGPR119 | |
| SCHEMBL22227 | 0.77 | HSD17B10 (0.51) | USP2SMN1; SMN2HSD17B10HPGDGPR119 | |
| SCHEMBL18027 | 0.77 | HSD17B10 (0.51) | USP2SMN1; SMN2HSD17B10HPGDGPR119 | |
| SCHEMBL20051384 | 0.74 | HSD17B10 (0.43) | USP2SMN1; SMN2HSD17B10HPGDUSP30 | |
| SCHEMBL31483 | 0.74 | HPGD (0.47) | RECQLHSD17B10HPGDMAPTMEN1 | |
| SCHEMBL14841356 | 0.74 | HPGD (0.47) | RECQLUSP2SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL27671652 | 0.73 | HSD17B10 (0.42) | USP2SMN1; SMN2HSD17B10HPGDUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009831-A1 | Pyrrolo[1,2-a]pyrazine-8-carboxamides are JNK inhibitors, useful as anticarcinogenic agents | AVENTIS PHARMA S.A, (FR) | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009831-A1 | Pyrrolo[1,2-a]pyrazine-8-carboxamides are JNK inhibitors, useful as anticarcinogenic agents | CNKSR1, ROS1, NRAS | RECQL 4053/4885USP2 3538/4885SMN1; SMN2 4434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.