Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.50 |
| ▸ | FLT1 | P17948 | 10/20 | 0.50 |
| ▸ | MET | P08581 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5240765 | 1.00 | KDR (0.50) | KDRFLT1METADORA3ADORA2A | |
| SCHEMBL5241567 | 0.93 | KDR (0.49) | KDRFLT1METADORA3ADORA2A | |
| SCHEMBL5243390 | 0.93 | KDR (0.49) | KDRFLT1METADORA3ADORA2A | |
| SCHEMBL5244286 | 0.91 | KDR (0.48) | KDRFLT1MET | |
| SCHEMBL5242187 | 0.89 | KDR (0.47) | KDRFLT1MET | |
| SCHEMBL5243195 | 0.89 | KDR (0.46) | KDRFLT1MET | |
| SCHEMBL5241428 | 0.87 | KDR (0.49) | KDRFLT1METADORA3ADORA2A | |
| SCHEMBL5242723 | 0.85 | KDR (0.46) | KDRFLT1MET | |
| SCHEMBL5241455 | 0.84 | KDR (0.48) | KDRFLT1MET | |
| SCHEMBL5240800 | 0.84 | KDR (0.41) | KDRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6869962-B2 | Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use | AGOURON PHARMACEUTICALS, INC. (US) | 2005-03-22 | — | — | US | disclosed |