Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 18/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | TEK | Q02763 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6532485 | 0.89 | EPHB4 (0.59) | EPHB4KDRTEK | |
| SCHEMBL6532481 | 0.87 | EPHB4 (0.53) | EPHB4KDRTEKMEN1LMNA | |
| SCHEMBL5483509 | 0.87 | EPHB4 (0.65) | EPHB4KDRTEK | |
| SCHEMBL5485397 | 0.83 | EPHB4 (0.64) | EPHB4KDRTEK | |
| SCHEMBL5485244 | 0.82 | EPHB4 (0.81) | EPHB4KDRTEK | |
| SCHEMBL5478522 | 0.76 | EPHB4 (0.76) | EPHB4KDRTEK | |
| SCHEMBL5474662 | 0.74 | EPHB4 (0.76) | EPHB4KDRTEK | |
| SCHEMBL5478521 | 0.74 | EPHB4 (0.81) | EPHB4KDRTEK | |
| SCHEMBL5474415 | 0.72 | EPHB4 (0.77) | EPHB4KDRTEK | |
| SCHEMBL5478464 | 0.71 | EPHB4 (0.78) | EPHB4KDRTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019220-A2 | SUBSTITUTED IMIDAZO[1,2-A]PYRAZINES AS MODULATORS OF KINASE ACTIVITY | CELLULAR GENOMICS INC. (US) | 2005-03-03 | — | — | WO | claimed |