Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.48 |
| ▸ | PIP5K1C | O60331 | 10/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | PIP5K1B | O14986 | 4/20 | 0.46 |
| ▸ | PIP5K1A | Q99755 | 4/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.46 |
| ▸ | PI4KA | P42356 | 3/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1518883 | 0.76 | MAPK10 (0.72) | JAK2TYK2ACVRL1PIP5K1CPIK3CA | |
| SCHEMBL21348455 | 0.71 | NPC1 (0.56) | JAK2TYK2TP53MAPK14HPGD | |
| SCHEMBL10537082 | 0.70 | HPGD (0.70) | TP53HPGDNPC1POLBRAB9A | |
| SCHEMBL21348452 | 0.69 | JAK2 (0.53) | JAK2TYK2MAPK14HPGDNPC1 | |
| SCHEMBL16392152 | 0.68 | HPGD (0.56) | TP53HPGDNPC1POLBRAB9A | |
| SCHEMBL27638921 | 0.67 | GCK (0.51) | JAK2TYK2PIP5K1CPIK3CANPC1 | |
| SCHEMBL6509374 | 0.67 | PIP5K1C (0.80) | PIP5K1CPIK3CAPIP5K1BPIP5K1APIK3CD | |
| SCHEMBL30642212 | 0.67 | JAK2 (0.64) | JAK2TYK2ACVRL1MAPK14HPGD | |
| SCHEMBL3515305 | 0.66 | TYK2 (1.00) | JAK2TYK2 | |
| SCHEMBL6502898 | 0.66 | PIP5K1C (0.81) | PIP5K1CPIK3CAPIP5K1BPIP5K1APIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003123-A1 | NOVEL PYRIDINE DERIVATIVES AS JNK SPECIFIC INHIBITORS | ASTRAZENECA AB (SE) | 2005-01-13 | — | — | WO | disclosed |