Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 5/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.48 |
| ▸ | ACP1 | P24666 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6534517 | 1.00 | KMT2A (0.59) | KMT2AMEN1LMNAADRB2POLB | |
| Hydrochloric Acid SCHEMBL6534523 | 0.99 | KMT2A (0.59) | KMT2AMEN1LMNAADRB2POLB | |
| Hydrochloric Acid SCHEMBL6534521 | 0.99 | KMT2A (0.59) | KMT2AMEN1LMNAADRB2POLB | |
| SCHEMBL6534367 | 0.98 | KMT2A (0.56) | KMT2AMEN1LMNAADRB2POLB | |
| SCHEMBL6534362 | 0.98 | KMT2A (0.56) | KMT2AMEN1LMNAADRB2POLB | |
| Hydrochloric Acid SCHEMBL6534259 | 0.97 | KMT2A (0.56) | KMT2AMEN1LMNAADRB2POLB | |
| Hydrochloric Acid SCHEMBL6534254 | 0.97 | KMT2A (0.56) | KMT2AMEN1LMNAADRB2POLB | |
| Hydrochloric Acid SCHEMBL6534648 | 0.95 | KMT2A (0.53) | KMT2AMEN1LMNAADRB2POLB | |
| Hydrochloric Acid SCHEMBL6534649 | 0.95 | KMT2A (0.53) | KMT2AMEN1LMNAADRB2POLB | |
| SCHEMBL6534248 | 0.82 | CYP2D6 (0.62) | LMNAADRB2HTR1AADRB1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1088818-B1 | Quinolin-4-yl derivatives | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | claimed |
| US-6440995-B1 | NMDA-RECEPTOR SUBTYPE SELECTIVE BLOCKERS | HOFFMAN-LA ROCHE INC. | 2002-08-27 | — | — | US | claimed |
| EP-1088818-A1 | Quinolin-4-yl derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-04 | — | — | EP | claimed |
| EP-1088818-B1 | Quinolin-4-yl derivatives | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |
| US-6440995-B1 | NMDA-RECEPTOR SUBTYPE SELECTIVE BLOCKERS | HOFFMAN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1088818-A1 | Quinolin-4-yl derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-04 | — | — | EP | disclosed |