SCHEMBL6535131

SCHEMBL6535131

CCOC(CCSCCC(OCC)c1ccccc1O)c1ccccc1O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.44
GABRA1 P14867 1/20 0.40
GABRB2 P47870 1/20 0.40
POLB P06746 1/20 0.37
PTPN2 P17706 1/20 0.34
PTPN1 P18031 1/20 0.34
HTR1A P08908 1/20 0.33
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA7 P43166 1/20 0.32
CA9 Q16790 1/20 0.32
CA14 Q9ULX7 1/20 0.32
PTPN9 P43378 1/20 0.32
GAA P10253 2/20 0.31
KDM4E B2RXH2 2/20 0.31
BCHE P06276 1/20 0.31
TYR P14679 1/20 0.31
ACHE P22303 1/20 0.31
METAP2 P50579 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22444530 0.85 TSHR (0.48) TSHRGABRA1GABRB2POLBPTPN2
SCHEMBL22444756 0.82 TSHR (0.46) TSHRGABRA1GABRB2POLBPTPN2
SCHEMBL22444462 0.81 TSHR (0.57) TSHRGABRA1GABRB2POLBPTPN2
SCHEMBL22444743 0.81 TSHR (0.44) TSHRGABRA1GABRB2POLBMEN1
SCHEMBL369707 0.79 TSHR (0.43) TSHRGABRA1GABRB2POLBMEN1
SCHEMBL8524308 0.79 TSHR (0.43) TSHRGABRA1GABRB2POLBMEN1
SCHEMBL22444758 0.79 TSHR (0.43) TSHRGABRA1GABRB2POLBMEN1
SCHEMBL22444453 0.79 TSHR (0.43) TSHRGABRA1GABRB2POLBMEN1
SCHEMBL10636536 0.78 TSHR (0.42) TSHRGABRA1GABRB2POLBMEN1
SCHEMBL6535412 0.77 SLC6A4 (0.37) TSHRGABRA1GABRB2POLBMETAP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0958275-A4 SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 UNIV VANDERBILT (US) 2004-12-01 EP disclosed
US-6284918-B1 ENZYME INHIBITORS VANDERBILT UNIVERSITY 2001-09-04 US disclosed
EP-0958275-A1 SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 VANDERBILT UNIVERSITY (US) 1999-11-24 EP disclosed
US-5973191-A AN ACETOXYPHENYLALKYL SULFIDE, SALT OR HYDRATE VANDERBILT UNIVERSITY (US) 1999-10-26 US disclosed
WO-1998029382-A1 SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 VANDERBILT UNIVERSITY (US) 1998-07-09 WO disclosed