Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 15/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.55 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.54 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.54 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | PLG | P00747 | 1/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.54 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.54 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5368733 | 0.93 | GRIN2B (0.60) | GRIN2BCYP2D6CYP2C9TPSAB1TPSD1 | |
| SCHEMBL14438481 | 0.90 | GRIN2B (0.62) | GRIN2BCYP2D6CYP2C9TPSAB1TPSD1 | |
| SCHEMBL5370917 | 0.90 | GRIN2B (0.59) | GRIN2BCYP2D6CYP2C9TPSAB1TPSD1 | |
| SCHEMBL5364448 | 0.88 | GRIN2B (0.57) | GRIN2BCYP2D6CYP2C9TPSAB1TPSD1 | |
| SCHEMBL5370887 | 0.88 | GRIN2B (0.57) | GRIN2BCYP2D6CYP2C9TPSAB1TPSD1 | |
| SCHEMBL5365292 | 0.88 | GRIN2B (0.61) | GRIN2BCYP2D6CYP2C9TPSAB1TPSD1 | |
| SCHEMBL5367461 | 0.86 | GRIN2B (0.61) | GRIN2BCYP2D6CYP2C9TPSAB1TPSD1 | |
| SCHEMBL5369779 | 0.86 | GRIN2B (0.61) | GRIN2BCYP2D6CYP2C9TPSAB1TPSD1 | |
| SCHEMBL5365134 | 0.86 | GRIN2B (0.61) | GRIN2BCYP2D6CYP2C9TPSAB1TPSD1 | |
| SCHEMBL5369615 | 0.86 | GRIN2B (0.61) | GRIN2BCYP2D6CYP2C9TPSAB1TPSD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399160-A4 | NR2B RECEPTOR ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF MIGRAINES | MERCK & CO INC (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-1399160-A2 | NR2B RECEPTOR ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF MIGRAINES | Merck & Co., Inc. (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2002100352-A2 | NR2B RECEPTOR ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF MIGRAINES | MERCK & CO., INC. (US) | 2002-12-19 | — | — | WO | disclosed |