Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 15/20 | 0.52 |
| ▸ | JAK2 | O60674 | 5/20 | 0.52 |
| ▸ | JAK1 | P23458 | 3/20 | 0.52 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6538037 | 0.96 | TYK2 (0.53) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL6538207 | 0.85 | TYK2 (0.51) | TYK2JAK2JAK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6537885 | 0.85 | TYK2 (0.51) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL6538304 | 0.83 | TYK2 (0.52) | TYK2JAK2JAK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6538041 | 0.83 | TYK2 (0.49) | TYK2JAK2JAK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6537924 | 0.83 | TYK2 (0.50) | TYK2JAK2JAK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8472633 | 0.83 | TYK2 (0.49) | TYK2JAK2JAK1SMN1; SMN2ALDH1A1 | |
| Dimethylamine SCHEMBL8474406 | 0.83 | TYK2 (0.49) | TYK2JAK2JAK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6537767 | 0.83 | TYK2 (0.53) | TYK2JAK2JAK1SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6538361 | 0.83 | JAK2 (0.49) | TYK2JAK2JAK1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |
| EP-0876345-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997014681-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-24 | — | — | WO | disclosed |