Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 5/20 | 0.50 |
| ▸ | JAK2 | O60674 | 4/20 | 0.50 |
| ▸ | JAK1 | P23458 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6537958 | 0.89 | SMN1; SMN2 (0.48) | HSD17B10HTTTYK2JAK2JAK1 | |
| SCHEMBL6537462 | 0.87 | TYK2 (0.49) | HSD17B10HTTTYK2JAK2JAK1 | |
| SCHEMBL8475365 | 0.85 | JAK2 (0.47) | HTTTYK2JAK2JAK1MEN1 | |
| SCHEMBL6537682 | 0.85 | TYK2 (0.47) | HSD17B10HTTTYK2JAK2JAK1 | |
| SCHEMBL6538073 | 0.84 | TYK2 (0.56) | HTTTYK2JAK2JAK1MEN1 | |
| SCHEMBL6538084 | 0.84 | TYK2 (0.53) | HTTTYK2JAK2JAK1MEN1 | |
| SCHEMBL6537783 | 0.83 | TYK2 (0.44) | HSD17B10HTTTYK2JAK2JAK1 | |
| SCHEMBL6537785 | 0.83 | TYK2 (0.44) | HSD17B10HTTTYK2JAK2JAK1 | |
| SCHEMBL6538096 | 0.83 | PPIA (0.49) | HTTSLC40A1TYK2JAK2JAK1 | |
| SCHEMBL6537947 | 0.83 | TYK2 (0.46) | HSD17B10HTTTYK2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |