Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.54 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12042120 | 0.79 | DYRK1A (0.44) | PARP1CDK5CLK1CDK5R1ALDH1A1 | |
| SCHEMBL15367210 | 0.79 | DYRK1A (0.41) | PARP1CDK5CLK1CDK5R1ALDH1A1 | |
| SCHEMBL5370069 | 0.78 | PARP1 (0.54) | PARP1PDPK1CA12ALOX15SMN1; SMN2 | |
| SCHEMBL13857871 | 0.78 | PARP1 (0.39) | PARP1CDK5POLBALDH1A1PDPK1 | |
| SCHEMBL14854026 | 0.78 | PARP1 (0.54) | PARP1CDK5PDPK1CA12ALOX15 | |
| SCHEMBL29161408 | 0.74 | ABL1 (0.56) | PARP1POLBRECQLALDH1A1SMN1; SMN2 | |
| SCHEMBL30734368 | 0.74 | ABL1 (0.56) | PARP1POLBRECQLALDH1A1SMN1; SMN2 | |
| SCHEMBL5675915 | 0.73 | CLK1 (0.50) | PARP1CDK5CLK1CDK5R1TDP1 | |
| SCHEMBL30036694 | 0.72 | PARP1 (0.43) | PARP1IMPDH2TDP1POLBRECQL | |
| SCHEMBL312428 | 0.72 | PARP1 (0.43) | PARP1IMPDH2TDP1POLBRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |
| US-4012371-A | Benzinaldazolyl-, quinolonyl-, or phenmorpholonylazo-3-cyano-4-methyl-1,2-[1',2']-benz-[4',5']-imidazolo-6-hydroxypyridine colorants | CIBA-GEIGY CORPORATION (US) | 1977-03-15 | — | — | US | disclosed |