Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 11/20 | 0.55 |
| ▸ | JAK2 | O60674 | 10/20 | 0.55 |
| ▸ | JAK1 | P23458 | 6/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6538203 | 0.87 | TYK2 (0.55) | TYK2JAK2JAK1KDRCYP3A4 | |
| SCHEMBL6538073 | 0.87 | TYK2 (0.56) | TYK2JAK2JAK1KDRCYP3A4 | |
| SCHEMBL6537972 | 0.86 | TYK2 (0.52) | TYK2JAK2JAK1CYP3A4CDK9 | |
| SCHEMBL6537461 | 0.86 | TYK2 (0.57) | TYK2JAK2JAK1KDRCYP3A4 | |
| SCHEMBL6538087 | 0.86 | TYK2 (0.51) | TYK2JAK2JAK1KDRCYP3A4 | |
| SCHEMBL6538163 | 0.86 | NR4A2 (0.57) | TYK2JAK2JAK1KDRCYP3A4 | |
| SCHEMBL6538110 | 0.85 | TYK2 (0.51) | TYK2JAK2JAK1KDRCYP3A4 | |
| SCHEMBL6537767 | 0.85 | TYK2 (0.53) | TYK2JAK2JAK1KDRCYP3A4 | |
| SCHEMBL6537718 | 0.84 | TYK2 (0.50) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL6536340 | 0.84 | TYK2 (0.50) | TYK2JAK2JAK1CDK9JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |
| EP-0876345-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997014681-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-24 | — | — | WO | disclosed |