Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | MELK | Q14680 | 1/20 | 0.43 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245388 | 0.78 | CCR8 (0.61) | CCR8KMT2AHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL11205036 | 0.77 | CCR8 (0.67) | CCR8KMT2AHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL29933981 | 0.76 | KDM4E (0.61) | CCR8KMT2AHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL15371410 | 0.76 | CCR8 (0.59) | CCR8KMT2AHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL15252375 | 0.76 | KDM4E (0.61) | CCR8KMT2AHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL15367385 | 0.76 | CCR8 (0.59) | CCR8KMT2AHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL19318056 | 0.75 | CCR8 (1.00) | CCR8KMT2AHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL30774416 | 0.75 | CCR8 (1.00) | CCR8KMT2AHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL6363005 | 0.74 | HSD17B10 (0.59) | CCR8KMT2AHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL6368302 | 0.74 | CCR8 (0.57) | CCR8KMT2AHSD17B10KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |