Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 8/20 | 0.45 |
| ▸ | JAK2 | O60674 | 7/20 | 0.45 |
| ▸ | JAK1 | P23458 | 5/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6537471 | 0.94 | TYK2 (0.47) | TYK2JAK2JAK1AURKAKDR | |
| SCHEMBL6537396 | 0.84 | TYK2 (0.41) | TYK2JAK2JAK1AURKAKDR | |
| SCHEMBL6538350 | 0.82 | TYK2 (0.43) | TYK2JAK2JAK1KDRHTT | |
| SCHEMBL6538120 | 0.80 | TYK2 (0.41) | TYK2JAK2JAK1KDRHTT | |
| SCHEMBL6537750 | 0.79 | TYK2 (0.42) | TYK2JAK2JAK1KDRHTT | |
| SCHEMBL6538139 | 0.78 | SCD (0.43) | TYK2JAK2JAK1KDRHTT | |
| SCHEMBL6538073 | 0.77 | TYK2 (0.56) | TYK2JAK2JAK1KDRHTT | |
| SCHEMBL6537888 | 0.77 | TYK2 (0.41) | TYK2JAK2JAK1AURKAKDR | |
| SCHEMBL6537421 | 0.76 | TYK2 (0.46) | TYK2JAK2JAK1KDRHTT | |
| SCHEMBL6538379 | 0.76 | TYK2 (0.43) | TYK2JAK2JAK1AURKAKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |