Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 15/20 | 0.74 |
| ▸ | ADRB1 | P08588 | 14/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | PPIA | P62937 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7531078 | 0.96 | ADRB3 (0.80) | ADRB3ADRB1MEN1KMT2AALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL6538900 | 0.89 | ADRB3 (0.78) | ADRB3ADRB1MEN1KMT2AADRB2 | |
| Trifluoroacetic Acid SCHEMBL6539346 | 0.88 | ADRB3 (0.76) | ADRB3ADRB1MEN1KMT2AALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL6538659 | 0.88 | ADRB3 (0.77) | ADRB3ADRB1MAPTADRB2 | |
| Trifluoroacetic Acid SCHEMBL6538530 | 0.88 | ADRB3 (0.76) | ADRB3ADRB1MEN1KMT2AMAPT | |
| Trifluoroacetic Acid SCHEMBL6539367 | 0.88 | ADRB3 (0.92) | ADRB3ADRB1MEN1KMT2AMAPT | |
| Trifluoroacetic Acid SCHEMBL6539325 | 0.88 | ADRB3 (0.76) | ADRB3ADRB1MEN1KMT2AMAPT | |
| Trifluoroacetic Acid SCHEMBL6538586 | 0.88 | ADRB3 (0.81) | ADRB3ADRB1MEN1KMT2AMAPT | |
| Trifluoroacetic Acid SCHEMBL6539537 | 0.86 | ADRB3 (0.81) | ADRB3ADRB1MEN1KMT2AMAPT | |
| SCHEMBL6538626 | 0.86 | ADRB3 (1.00) | ADRB3ADRB1ALDH1A1MAPTADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6826033-B2 | BETA 3 ADRENERGIC RECEPTOR AGONISTS; TREATMENT OF POLLAKIURIA, URINARY INCONTINENCE, OBESITY OR DIABETES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| US-20040037022-A1 | Aminoalcohol derivatives | ASTELLAS PHARMA INC. (JP) | 2004-02-26 | — | — | US | disclosed |