SCHEMBL6542927

SCHEMBL6542927

CC(C)(Oc1ccccc1CN(Cc1ccc(Cl)cc1)c1nc2ccccc2o1)C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 17/20 0.54
PPARG P37231 14/20 0.54
PPARD Q03181 12/20 0.54
CXCR4 P61073 1/20 0.40
NPC1 O15118 1/20 0.39
CSNK1D P48730 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7247837 0.92 PPARA (0.56) PPARAPPARGPPARD
SCHEMBL6544117 0.91 PPARA (0.57) PPARAPPARGPPARD
SCHEMBL6542969 0.90 PPARA (0.56) PPARAPPARGPPARD
SCHEMBL6544104 0.86 PPARA (0.54) PPARAPPARGPPARD
SCHEMBL2437112 0.84 PPARA (0.75) PPARAPPARGPPARD
SCHEMBL6544084 0.83 PPARA (0.58) PPARAPPARGPPARD
SCHEMBL6543018 0.83 PPARA (0.49) PPARAPPARGPPARDNPC1
SCHEMBL6542809 0.82 PPARA (0.67) PPARAPPARGPPARDCXCR4
SCHEMBL6542970 0.82 PPARA (0.62) PPARAPPARGPPARD
SCHEMBL2434140 0.81 PPARA (0.61) PPARAPPARGPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1433786-A1 Benzoxazole compound and pharmaceutical composition containing the compound Kowa Company Ltd. (JP) 2004-06-30 EP disclosed
US-6653334-B1 Electively activate peroxisome proliferator activated receptors KOWA CO., LTD. (JP) 2003-11-25 US disclosed