Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.31 |
| ▸ | PDE4A | P27815 | 2/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.31 |
| ▸ | F2R | P25116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6544040 | 0.90 | F2R (0.32) | MAPTKDM4ENPC1RAB9AF2R | |
| Bromide SCHEMBL1730266 | 0.76 | KDM4E (0.34) | MAPTKDM4ENPC1RAB9AF2R | |
| SCHEMBL27506130 | 0.75 | HSP90AA1 (0.42) | MAPTKDM4ENPC1RAB9AMEN1 | |
| Bromide SCHEMBL1729690 | 0.74 | F2R (0.35) | MAPTKDM4ENPC1RAB9AF2R | |
| Bromide SCHEMBL1731929 | 0.72 | F2R (0.36) | MAPTKDM4ENPC1RAB9AF2R | |
| Bromide SCHEMBL1731017 | 0.72 | KDM4E (0.34) | MAPTKDM4ENPC1RAB9AF2R | |
| Bromide SCHEMBL1731020 | 0.72 | F2R (0.41) | MAPTKDM4ENPC1RAB9AF2R | |
| Bromide SCHEMBL1730770 | 0.72 | F2R (0.54) | MAPTKDM4ENPC1RAB9AF2R | |
| Bromide SCHEMBL1732483 | 0.72 | PDE4B (0.34) | MAPTKDM4ENPC1RAB9APDE4B | |
| Bromide SCHEMBL6544436 | 0.71 | KDM4E (0.35) | MAPTKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391451-A1 | 2-IMINOPYRROLIDINE DERIVATES | Eisai Co., Ltd. (JP) | 2004-02-25 | — | — | EP | disclosed |