Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.62 |
| ▸ | GSK3A | P49840 | 15/20 | 0.58 |
| ▸ | SRC | P12931 | 13/20 | 0.56 |
| ▸ | SYK | P43405 | 13/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6546823 | 0.94 | MAPK14 (0.58) | MAPK14GSK3ASRCSYKLCK | |
| SCHEMBL6546253 | 0.91 | MAPK14 (0.60) | MAPK14GSK3ASRCSYKLCK | |
| SCHEMBL6546518 | 0.90 | MAPK14 (0.59) | MAPK14GSK3ASRCSYKLCK | |
| SCHEMBL6546714 | 0.89 | MAPK14 (0.62) | MAPK14GSK3ASRCSYKLCK | |
| SCHEMBL6547032 | 0.89 | MAPK14 (0.57) | MAPK14GSK3ASRCSYKLCK | |
| SCHEMBL6545790 | 0.86 | MAPK14 (0.58) | MAPK14GSK3ASRCSYKLCK | |
| SCHEMBL6546738 | 0.86 | GSK3A (0.59) | MAPK14GSK3ASRCSYKCYP3A4 | |
| SCHEMBL6546222 | 0.86 | MAPK14 (0.58) | MAPK14GSK3ASRCSYKLCK | |
| SCHEMBL6546724 | 0.86 | GSK3A (0.63) | MAPK14GSK3ASRCSYKLCK | |
| SCHEMBL6545968 | 0.85 | MAPK14 (0.64) | MAPK14GSK3ASRCSYKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1381592-A1 | 1,4-DISUBSTITUTED BENZO-FUSED COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-01-21 | — | — | EP | claimed |
| WO-2002083628-A1 | 1,4-DISUBSTITUTED BENZO-FUSED COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2002-10-24 | — | — | WO | claimed |
| US-6765009-B2 | N-(5-TERT-BUTYL-3-(3-(4-((2-DIMETHYLAMINOMETHYL-PYRIDIN-4-YL) -PIPERAZIN-1-YL-METHYL) NAPHTHALEN-1-YL)UREIDO)-2-METHOXYPHENYL) METHANESULFONAMIDE FOR EXAMPLE; CYTOKINE INHIBITORS FOR TREATMENT OF INFLAMMATORY DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-07-20 | — | — | US | disclosed |
| EP-1381592-A1 | 1,4-DISUBSTITUTED BENZO-FUSED COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-01-21 | — | — | EP | disclosed |
| WO-2002083628-A1 | 1,4-DISUBSTITUTED BENZO-FUSED COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2002-10-24 | — | — | WO | disclosed |