Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | LSS | P48449 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 5/20 | 0.46 |
| ▸ | KLK1 | P06870 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193868 | 0.82 | ATM (0.71) | ATMLSSL3MBTL1LMNAF10 | |
| Hydrochloric Acid SCHEMBL6195419 | 0.81 | ATM (0.69) | ATMLSSL3MBTL1LMNAF10 | |
| SCHEMBL5196283 | 0.78 | F10 (0.71) | LSSF10KLK1 | |
| SCHEMBL6306860 | 0.78 | LSS (0.50) | ATMLSSMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL6737310 | 0.78 | F10 (0.70) | ATMLSSKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL6731641 | 0.78 | LSS (0.52) | ATMLSSMEN1KMT2AALDH1A1 | |
| SCHEMBL6731057 | 0.77 | LSS (0.51) | ATMLSSMEN1KMT2AALDH1A1 | |
| SCHEMBL6730431 | 0.77 | LSS (0.53) | ATMLSSMEN1KMT2AALDH1A1 | |
| SCHEMBL6421733 | 0.77 | F10 (0.71) | ATMLSSALDH1A1L3MBTL1F10 | |
| SCHEMBL6725737 | 0.77 | LSS (0.50) | ATMLSSMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937048-B1 | HETEROCYCLE DERIVATIVES WHICH INHIBIT FACTOR Xa | ASTRAZENECA AB (SE) | 2004-01-21 | — | — | EP | disclosed |
| EP-1358909-A1 | Heteroaryl-phenyl derivatives as factor xa inhibitors for use as antithrombotic and anticoagulant agents | AstraZeneca AB (SE) | 2003-11-05 | — | — | EP | disclosed |
| US-6300330-B1 | BLOOD COAGULATION FACTOR X INHIBITORS AS ANTICOAGULANTS | ZENECA LIMITED (GB) | 2001-10-09 | — | — | US | disclosed |
| EP-0937048-A1 | HETEROCYCLE DERIVATIVES WHICH INHIBIT FACTOR Xa | ZENECA LIMITED (GB) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998021188-A1 | HETEROCYCLE DERIVATIVES WHICH INHIBIT FACTOR Xa | ZENECA LIMITED (GB) | 1998-05-22 | — | — | WO | disclosed |