SCHEMBL6548752

SCHEMBL6548752

ClC(/C=C/c1cccnc1)=N\OCCCN1CCCCC1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 2/20 0.45
HRH2 P25021 1/20 0.45
CHRNB2 P17787 1/20 0.42
CHRNA4 P43681 1/20 0.42
HRH3 Q9Y5N1 2/20 0.40
CLK2 P49760 3/20 0.40
CLK3 P49761 3/20 0.40
DYRK1A Q13627 3/20 0.40
CHRNA7 P36544 1/20 0.39
DRD2 P14416 1/20 0.39
DRD3 P35462 1/20 0.39
KDM4E B2RXH2 1/20 0.39
NPC1 O15118 1/20 0.39
JUN P05412 1/20 0.39
MAPT P10636 1/20 0.39
NFKB1 P19838 1/20 0.39
MAPK1 P28482 1/20 0.39
RAB9A P51151 1/20 0.39
GPR55 Q9Y2T6 1/20 0.39
SIGMAR1 Q99720 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6548755 1.00 HRH1 (0.45) HRH1HRH2CHRNB2CHRNA4HRH3
Fumaric Acid SCHEMBL7680912 0.94 HRH1 (0.45) HRH1HRH2HRH3CLK2CLK3
Maleic Acid SCHEMBL7680908 0.94 HRH1 (0.45) HRH1HRH2HRH3CLK2CLK3
SCHEMBL6548852 0.87 HSP90AA1 (0.51) HRH1HRH2HRH3DRD2DRD3
SCHEMBL6548849 0.87 HSP90AA1 (0.51) HRH1HRH2HRH3DRD2DRD3
Hydrochloric Acid SCHEMBL6549764 0.86 HRH1 (0.44) HRH1HRH2CHRNB2CHRNA4HRH3
SCHEMBL2324632 0.81 TAAR1 (0.54) HRH1HRH2CHRNB2CHRNA4HRH3
SCHEMBL30420765 0.81 TAAR1 (0.54) HRH1HRH2CHRNB2CHRNA4HRH3
SCHEMBL6549259 0.80 HSF1 (0.46) KDM4ENPC1JUNMAPTNFKB1
SCHEMBL6549255 0.80 HSF1 (0.46) KDM4ENPC1JUNMAPTNFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1115697-B1 UNSATURATED HYDROXIMIC ACID DERIVATIVES AS PARP INHIBITORS GENE KUTATO KFT N (HU) 2004-02-04 EP disclosed
US-6500823-B1 ENERGY DEFICIENCY OF THE CELL CAUSED BY PARP INHIBITION, IN DIABETES COMPLICATIONS, IN OXYGEN DEFICIENT STATUS OF THE HEART AND BRAIN, IN NEURODEGENERATIVE DISEASES, IN THE TREATMENT OF AUTOIMMUNE AND/OR VIRAL DISEASES N-GENE RESEARCH LABORATORIES, INC. 2002-12-31 US disclosed
EP-1115697-A1 UNSATURATED HYDROXIMIC ACID DERIVATIVES AS PARP INHIBITORS N-Gene Kutato KFT. (HU) 2001-07-18 EP disclosed
WO-2000014054-A1 UNSATURATED HYDROXIMIC ACID DERIVATIVES AS PARP INHIBITORS N-Gene Kutató Kft. (HU) 2000-03-16 WO disclosed