Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 16/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.51 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.44 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.44 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.44 |
| ▸ | PI4KA | P42356 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6549107 | 0.98 | PIK3CD (0.51) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL6550348 | 0.89 | PIK3CD (0.50) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL5783825 | 0.85 | PIK3CG (0.64) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL6550300 | 0.84 | PIK3CD (0.53) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| Sulfuric Acid SCHEMBL17203104 | 0.84 | PIK3CG (0.62) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL5782116 | 0.84 | PIK3CD (0.48) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| Sulfuric Acid SCHEMBL17203140 | 0.83 | PIK3CG (0.61) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| Sulfuric Acid SCHEMBL17203055 | 0.83 | PIK3CG (0.61) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL49031 | 0.82 | PIK3CD (0.73) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL17203053 | 0.81 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1480962-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS | Novartis AG (CH) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003072557-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS | NOVARTIS AG (CH) | 2003-09-04 | — | — | WO | disclosed |