Tetrahydrofuran

Tetrahydrofuran

SCHEMBL6549974

C1CCOC1.CCCC1CCCO1

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 1/20 0.45
LMNA P02545 1/20 0.37
POLB P06746 1/20 0.37
USP2 O75604 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
HPGD P15428 2/20 0.36
TP53 P04637 1/20 0.36
ALOX12 P18054 1/20 0.36
ALDH1A1 P00352 3/20 0.35
KMT2A Q03164 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12424265 0.91
SCHEMBL2632847 0.91
SCHEMBL105953 0.91
SCHEMBL2715836 0.89
SCHEMBL22732629 0.89
Tetrahydrofuran SCHEMBL29168530 0.88 EPHX1 (0.57) EPHX1LMNAPOLBUSP2SMN1; SMN2
SCHEMBL8051310 0.87 EPHX1 (0.48) EPHX1KMT2A
Water SCHEMBL2197126 0.87 EPHX1 (0.48) EPHX1KMT2A
SCHEMBL31055743 0.87 EPHX1 (0.48) EPHX1HPGDKMT2A
Methoxymethane SCHEMBL28364081 0.85 EPHX1 (0.47) EPHX1LMNAPOLBUSP2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016131590-A1 MULTIVINYLAMINOSILANES AS BRANCHING AGENTS FOR FUNCTIONALIZED ELASTOMERIC POLYMERS TRINSEO EUROPE GMBH (CH) 2016-08-25 WO disclosed
EP-0984038-B1 Hydrogenated block copolymers having a partially branched structure POLIMERI EUROPA SPA (IT) 2004-02-04 EP disclosed
US-6235841-B1 HAVING AN OPTIMUM BALANCE BETWEEN MECHANICAL PROPERTIES AND RHEOLOGICAL PROPERTIES. ENICHEM S.P.A. (IT) 2001-05-22 US disclosed
EP-0816382-B1 Process for the preparation of a catalyst useful for the hydrogenation of styrene-butadiene copolymers ENICHEM SPA (IT) 2000-12-27 EP disclosed
EP-0984038-A1 Hydrogenated block copolymers having a partially branched structure Enichem S.p.A. (IT) 2000-03-08 EP disclosed
US-5948869-A COORDINATION CATALYST ENICHEM S.P.A. (IT) 1999-09-07 US disclosed
EP-0816382-A1 Process for the preparation of a catalyst useful for the hydrogenation of styrene-butadiene copolymers ENICHEM S.p.A. (IT) 1998-01-07 EP disclosed